DEEP BRAIN STIMULATION OF THE POSTERIOR HYPOTHALAMIC NUCLEUS REVERSES AKINESIA IN BILATERALLY 6-HYDROXYDOPAMINE-LESIONED RATS
Identifieur interne : 002111 ( Main/Exploration ); précédent : 002110; suivant : 002112DEEP BRAIN STIMULATION OF THE POSTERIOR HYPOTHALAMIC NUCLEUS REVERSES AKINESIA IN BILATERALLY 6-HYDROXYDOPAMINE-LESIONED RATS
Auteurs : C. K. Young [Canada] ; S. J. Koke [Canada] ; Z. H. Kiss [Canada] ; B. H. Bland [Canada]Source :
- Neuroscience [ 0306-4522 ] ; 2009.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Deep brain stimulation (DBS) of the basal ganglia motor circuitry is a highly effective treatment for the debilitating motor symptoms of Parkinson's disease (PD). However, recent findings have indicated promising potential for PD therapy with DBS in brain structures outside the basal ganglia. For example, high frequency stimulation of the posterior hypothalamic nucleus (PH) can reverse haloperidol-induced akinesia in rats [Jackson J, Young CK, Hu B, Bland BH (2008) High frequency stimulation of the posterior hypothalamic nucleus restores movement and reinstates hippocampal-striatal theta coherence following haloperidol-induced catalepsy. Exp Neurol 213:210- 219]. In the current study, we used the bilateral 6-hydroxydopamine lesion model of Parkinsonian akinesia in male Long-Evans rats to further explore the efficacy of PH DBS. The application of PH DBS in lesioned animals reversed akinesia in an active avoidance paradigm with increased latency compared to pre-lesion performance. The dramatic reversal of akinesia in two models of rodent Parkinsonism by PH DBS warrants further exploration of its therapeutic potential.
Affiliations:
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K." last="Young">C. K. Young</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Psychology, Behavioral Neuroscience Research Group, Hotchkiss Brain Institute, University of Calgary, 2500 University Drive Northwest</s1><s2>Calgary, AB, T2N 1N4</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Calgary, AB, T2N 1N4</wicri:noRegion><orgName type="university">Université de Calgary</orgName><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName></affiliation></author><author><name sortKey="Koke, S J" sort="Koke, S J" uniqKey="Koke S" first="S. J." last="Koke">S. J. Koke</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Psychology, Behavioral Neuroscience Research Group, Hotchkiss Brain Institute, University of Calgary, 2500 University Drive Northwest</s1><s2>Calgary, AB, T2N 1N4</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Calgary, AB, T2N 1N4</wicri:noRegion><orgName type="university">Université de Calgary</orgName><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary</s1><s2>Calgary, AB, T2N 1N4</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName><orgName type="university">Université de Calgary</orgName></affiliation></author><author><name sortKey="Kiss, Z H" sort="Kiss, Z H" uniqKey="Kiss Z" first="Z. H." last="Kiss">Z. H. Kiss</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary</s1><s2>Calgary, AB, T2N 1N4</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName><orgName type="university">Université de Calgary</orgName></affiliation></author><author><name sortKey="Bland, B H" sort="Bland, B H" uniqKey="Bland B" first="B. H." last="Bland">B. H. Bland</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Psychology, Behavioral Neuroscience Research Group, Hotchkiss Brain Institute, University of Calgary, 2500 University Drive Northwest</s1><s2>Calgary, AB, T2N 1N4</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Calgary, AB, T2N 1N4</wicri:noRegion><orgName type="university">Université de Calgary</orgName><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Neuroscience</title><title level="j" type="abbreviated">Neuroscience</title><idno type="ISSN">0306-4522</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neuroscience</title><title level="j" type="abbreviated">Neuroscience</title><idno type="ISSN">0306-4522</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Akinesia</term><term>Animal</term><term>Avoidance</term><term>Deep brain stimulation</term><term>Haloperidol</term><term>High frequency</term><term>Hypothalamus</term><term>Lesion</term><term>Medial forebrain bundle</term><term>Oxidopamine</term><term>Parkinson disease</term><term>Rat</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Hypothalamus</term><term>Akinésie</term><term>Oxidopamine</term><term>Lésion</term><term>Faisceau médian télencéphale</term><term>Haute fréquence</term><term>Evitement</term><term>Halopéridol</term><term>Maladie de Parkinson</term><term>Rat</term><term>Animal</term><term>Stimulation cérébrale profonde</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Deep brain stimulation (DBS) of the basal ganglia motor circuitry is a highly effective treatment for the debilitating motor symptoms of Parkinson's disease (PD). However, recent findings have indicated promising potential for PD therapy with DBS in brain structures outside the basal ganglia. For example, high frequency stimulation of the posterior hypothalamic nucleus (PH) can reverse haloperidol-induced akinesia in rats [Jackson J, Young CK, Hu B, Bland BH (2008) High frequency stimulation of the posterior hypothalamic nucleus restores movement and reinstates hippocampal-striatal theta coherence following haloperidol-induced catalepsy. Exp Neurol 213:210- 219]. In the current study, we used the bilateral 6-hydroxydopamine lesion model of Parkinsonian akinesia in male Long-Evans rats to further explore the efficacy of PH DBS. The application of PH DBS in lesioned animals reversed akinesia in an active avoidance paradigm with increased latency compared to pre-lesion performance. The dramatic reversal of akinesia in two models of rodent Parkinsonism by PH DBS warrants further exploration of its therapeutic potential.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Alberta</li></region><settlement><li>Calgary</li></settlement><orgName><li>Université de Calgary</li></orgName></list><tree><country name="Canada"><region name="Alberta"><name sortKey="Young, C K" sort="Young, C K" uniqKey="Young C" first="C. K." last="Young">C. K. Young</name></region><name sortKey="Bland, B H" sort="Bland, B H" uniqKey="Bland B" first="B. H." last="Bland">B. H. Bland</name><name sortKey="Kiss, Z H" sort="Kiss, Z H" uniqKey="Kiss Z" first="Z. H." last="Kiss">Z. H. Kiss</name><name sortKey="Koke, S J" sort="Koke, S J" uniqKey="Koke S" first="S. J." last="Koke">S. J. Koke</name><name sortKey="Koke, S J" sort="Koke, S J" uniqKey="Koke S" first="S. J." last="Koke">S. J. 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